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경도인지장애 노인의 Apo E genotype과 신체활동이 homocysteine, hs-CRP, plasma antioxidants 및 lipid profile에 미치는 영향
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | 김지용 | - |
| dc.date.accessioned | 2017-02-22T05:22:18Z | - |
| dc.date.available | 2017-02-22T05:22:18Z | - |
| dc.date.issued | 2012 | - |
| dc.date.submitted | 56987-11-06 | - |
| dc.identifier.uri | http://kmou.dcollection.net/jsp/common/DcLoOrgPer.jsp?sItemId=000002174559 | ko_KR |
| dc.identifier.uri | http://repository.kmou.ac.kr/handle/2014.oak/8607 | - |
| dc.description.abstract | The degenerative Alzheimer's disease(AD) gradually occur and progress, and mild cognitive impairment is clinically important as an indicator of AD. This study attempted to classify a mild cognitive impairment(MCI) group of 10 and another normal control(NC) group of 10 after MMSE tests and utilize Borg's scale of physical activity on which the aged over 65 participated in 'Uri Dance Gymnastics' with 12 to 14 intensity, twice a week, 120 minutes a day in the period of 12 weeks. Accordingly, repeated measured ANOVA(RM ANOVA), independent and paired t-tests at the significant level of a=.05 revealed following findings. First, the most frequent Apo E genotypes included E3, E4 and E2 in order. In specific, E2 frequently occurred in NC but E4 in MCI. Second, RM ANOVA revealed a significant effect of group factor on levels of Homocysteine. In specific, it was found that the MCI group had significantly higher levels of Homocysteine in both pre and post physical activity but levels of Homocysteine significantly decreased only in the NC group. Third, RM ANOVA revealed a significant effect of group factor on levels of hs-CRP. However, following post-hoc tests indicated no significant effects of both physical activity and group factors. Fourth, RM ANOVA revealed significant effects of group factor on levels of uric acid and Total bilirubin. The MCI group had significantly higher levels of uric acid but lower levels of Total bilirubin in both pre and post physical activity. Fifth, a significant interaction effect was found in Total cholesterol and a significant decrease occurred only in the NC group. HDL-C had a significant group effect and the NC group had significantly higher levels of HDL-C. In addition, LDL-C had a significant interaction effect between physical activity and group factors but a significant difference occurred only in the NC group. In conclusion, it is implied that the physical activity can generate positive effects on biochemical factors associated with AD. Therefore, it is expected that the aged over 65 with a high mobility rate of AD can benefit from participating in physical activities and physical activities can contribute to preventing degenerative diseases in the aged society. | - |
| dc.description.tableofcontents | LIST OF TABLES ⅲ LIST OF FIGURES ⅳ ABSTRACT ⅴ Ⅰ. 서론 1 1. 연구의 필요성 1 2. 연구의 목적 3 3. 연구의 문제 4 4. 용어의 정의 4 Ⅱ. 이론적 배경 5 1. 인지기능 5 2. Apolipoprotein E 6 3. Homocysteine 9 4. hs-CRP 11 5. Plasma antioxidants 12 Ⅲ. 연구방법 14 1. 연구대상 14 2. 연구절차 15 3. 측정방법 16 4. 신체활동 프로그램 25 5. 자료분석 26 Ⅳ. 결과 27 1. Apo E genotype의 상대빈도수 27 2. Homocysteine 29 3. hs-CRP 30 4. Plasma antioxidants 31 5. Lipid profile 34 Ⅴ. 논의 38 1. Apo E genotype 38 2. Homocysteine 39 3. hs-CRP 40 4. Plasma antioxdants 41 5. Lipid profile 42 Ⅵ. 결론 45 참고문헌 47 LIST OF TABLES Table 1. The codon type of Apo E allele 7 Table 2. Physical characteristics of subjects 14 Table 3. PCR master mix solution 18 Table 4. Cycle for PCR 19 Table 5. Program configuration 25 Table 6. Number of Apo E genotype 27 Table 7. Comparisons of homocysteine 29 Table 8. Result of two-way repeated ANOVA for homocysteine 29 Table 9. Comparisons of hs-CRP 30 Table 10. Result of two-way repeated ANOVA for hs-CRP 30 Table 11. Comparisons of albumin 31 Table 12. Result of two-way repeated ANOVA for albumin 31 Table 13. Comparisons of uric acid 32 Table 14. Result of two-way repeated ANOVA for uric acid 32 Table 15. Comparisons of total bilirubin 33 Table 16. Result of two-way repeated ANOVA for total bilirubin 33 Table 17. Comparisons of total cholesterol 34 Table 18. Result of two-way repeated ANOVA for total cholesterol 34 Table 19. Comparisons of HDL-C 35 Table 20. Result of two-way repeated ANOVA for HDL-C 35 Table 21. Comparisons of LDL-C 36 Table 22. Result of two-way repeated ANOVA for LDL-C 36 Table 23. Comparisons of triglyceride 37 Table 24. Result of two-way repeated ANOVA for triglyceride 37 LIST OF FIGURES Figure 1. Metabolism of homocysteine 10 Figure 2. Research procedures 15 Figure 3. Examples of results with the Apo E 20 Figure 4. BCG method for albumin 21 Figure 5. Enzymatic method for uric acid 22 Figure 6. Colorimetric method for total bilirubin 22 Figure 7. Enzymatic method for total cholesterol 23 Figure 8. Apo E genotype distribution 28 | - |
| dc.language | kor | - |
| dc.publisher | 한국해양대학교 해양관리기술대학원 | - |
| dc.title | 경도인지장애 노인의 Apo E genotype과 신체활동이 homocysteine, hs-CRP, plasma antioxidants 및 lipid profile에 미치는 영향 | - |
| dc.title.alternative | The Effects of Apo E Genotype and Physical Activity on Homocysteine, hs-CRP, Plasma Antioxidants and Lipid Profile of the Aged with Mild Cognitive Impairment | - |
| dc.type | Thesis | - |
| dc.date.awarded | 2012-02 | - |
| dc.contributor.alternativeName | Kim Ji-Yong | - |
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